Academy Statement on Autism and Folate

September 26, 2025 – The Academy of Nutrition and Dietetics believes that we need to promote evidence-based treatments for complex conditions such as autism spectrum disorder (ASD). ASD is a developmental condition influenced by a wide range of genetic, biological, and environmental factors. The autism spectrum is broad and while there are several described risk factors, there is no consensus that any single exposure or parenting practice has a direct causal link to ASD.

Earlier this week, the Administration put forth a variety of causal links to ASD, including folate. The current evidence does not strongly support such a claim.

Established research continues to show that adequate maternal folate intake before and during pregnancy is critical for preventing neural tube defects and supporting healthy neurodevelopment. Further, Leucovorin (a prescription formulation of a type of folate, folinic acid) is not currently a recommended treatment for ASD. The Academy is aware of existing theories about cerebral folate insufficiency and ASD, and encourages the Administration to fund research to determine whether or not Leucovorin would be an appropriate and effective treatment for individuals with autism.

It is imperative to promote evidence-based nutrition therapies to families who need them while advancing rigorous research to test the validity of new treatments. For children with ASD, this includes support from registered dietitian nutritionists given the higher likelihood of food selectivity, supportive care needs and individualized nutritional needs.